Abstract
A series of 11 novel 3beta-substituted biphenyltropanes was synthesized and evaluated by selective radioligand binding assays for affinity to monoamine transporters. Both 5-HTT potency and selectivity for 5-HTT over DAT was greatest with electron withdrawing group at the 3''-position.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carrier Proteins / metabolism*
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Cocaine / chemistry
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Dopamine
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins*
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Molecular Structure
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Nerve Tissue Proteins*
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Norepinephrine
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Norepinephrine Plasma Membrane Transport Proteins
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Prosencephalon / drug effects
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Prosencephalon / metabolism
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Radioligand Assay
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Rats
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Serotonin
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Serotonin Plasma Membrane Transport Proteins
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Symporters*
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Tropanes / chemical synthesis
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Tropanes / chemistry*
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Tropanes / metabolism*
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Norepinephrine Plasma Membrane Transport Proteins
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Serotonin Plasma Membrane Transport Proteins
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Slc6a2 protein, rat
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Slc6a3 protein, rat
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Slc6a4 protein, rat
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Symporters
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Tropanes
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Serotonin
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Cocaine
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Dopamine
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Norepinephrine